Type I collagen

src: www.columbia.edu

Type I collagen is the most abundant collagen of the human body that forms a large eosinophilic fiber known as collagen fiber. It is present in scar tissue, the end product when tissue heals with repair, as well as tendons, ligaments, endomisium myofibrils, organic parts of bones, dermis, dentine capsules and organs.

Video Type I collagen

Formation

The COL1A1 gene produces a pro-alpha (I) chain. These chains combine with other pro-alpha (I) chains as well as with the pro-alpha (I) chain (produced by the COL1A2 gene) to make the type I procollagen molecule. These three-wavy, wavy procollagen molecules must be processed by enzymes in outside the cell. Once these molecules are processed, they regulate themselves into long, thin fibrils that bind to each other in the space around the cell. Crosslinks result in the formation of very strong adult type collagen fibers.

Maps Type I collagen

Clinical interests

See Collagen, type I, alpha 1 # Clinical significance

src: ard.bmj.com

See also

• Collagen
• Collagen type II
• Collagen, type III, alpha 1
• COL1A1
• COL1A2

src: www.pnas.org

External links

• Type I collagen at US National Library of Medicine Subject Medical Headings (MeSH)

src: jcb.rupress.org

References

• Junqueira Basic Histology , p106

Source of the article : Wikipedia